Double stranded break repair

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As can be seen: HRR only works when there is a homologous strand of DNA available, i.e, DNA duplication has already occurred during the cell cycle. Hence this sort of repair is most active in the G2 phase (after the S phase of DNA synthesis)

 

Note: MRN complex is composed of Nbs 1 (deficient in Nijmegen breakage syndrome), Rad 50 and Mre11

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