Thank you. 5mm is probably appropriate. Traditional margins were 2cm but we have moved away from that. Others tend to vary margin according to grade (5mm for grade 1 and 10mm for grade 2/3. But overall 5mm is reasonable. Best to back it up with evidence rather than heresay though! https://pubmed.ncbi.nlm.nih.gov/22818137/
Thank you. I had a read of this paper as well in addition to the one you mentioned.
From exam point of view , I guess the exam answer will depend on the grade and LVSI and applying this risk adopted algorithm to the individual case ?
Hi, not sure how I can help you? Do you mean the formatting is off (I’ve checked and it seems okay?). Are you able to provide any further details of what you mean by messy please? Thanks
Hi, small cell bladder cancer is a rare cancer so there isn’t one right way to treat this disease. I would agree that neoadjuvant therapy followed by radiotherapy is reasonable. If very early stage surgery isn’t wrong either for local control. However in general small cell anywhere in the body is seen as a disease with high risk of systemic dissemination and micrometastases and chemotherapy is crucial.
The CLINICAL ONCOLOGY REGISTRAR 
Hi there, the renal/bladder document is missing? Can this be updated please! Thanks in advance.
LikeLike
Hi, Sorry about this. Not sure what happened. I have re-linked the software and hopefully should be working now
LikeLike
Hmm sorry doesn’t seem to be working
LikeLike
Hmm, I think finally sorted.
LikeLiked by 1 person
Talking about “Total penectomy with perineal urethrostomy
o Aim 10 mm margin””
I think 5 mm margin is acceptable these days from what I understand from talks of people from Marsden?
LikeLike
Thank you. 5mm is probably appropriate. Traditional margins were 2cm but we have moved away from that. Others tend to vary margin according to grade (5mm for grade 1 and 10mm for grade 2/3. But overall 5mm is reasonable. Best to back it up with evidence rather than heresay though! https://pubmed.ncbi.nlm.nih.gov/22818137/
LikeLike
Thank you. I had a read of this paper as well in addition to the one you mentioned.
From exam point of view , I guess the exam answer will depend on the grade and LVSI and applying this risk adopted algorithm to the individual case ?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988642/#:~:text=Another%20study%2C%20by%20Sri%20et,low%20risk%20of%20local%20recurrence.&text=As%20such%20EAU%20guidelines%20have,negative%20histopathological%20margin%20is%20adequate
LikeLike
Hi do you mind re-arrange the notes? its bit messy here..
LikeLike
Hi, not sure how I can help you? Do you mean the formatting is off (I’ve checked and it seems okay?). Are you able to provide any further details of what you mean by messy please? Thanks
LikeLike
Hi
Could you clarify regarding small cell bladder cancer – so here we dont do surgery ?
only NACT followed by RT ?
LikeLike
Hi, small cell bladder cancer is a rare cancer so there isn’t one right way to treat this disease. I would agree that neoadjuvant therapy followed by radiotherapy is reasonable. If very early stage surgery isn’t wrong either for local control. However in general small cell anywhere in the body is seen as a disease with high risk of systemic dissemination and micrometastases and chemotherapy is crucial.
LikeLike